Antibody-Mediated Phagocytosis of the Amyloid b-Peptide in Microglia Is Differentially Modulated by C1q
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چکیده
منابع مشابه
Antibody-mediated phagocytosis of the amyloid beta-peptide in microglia is differentially modulated by C1q.
Microglial ingestion of the amyloid beta-peptide (Abeta) has been viewed as a therapeutic target in Alzheimer's disease, in that approaches that enhance clearance of Abeta relative to its production are predicted to result in decreased senile plaque formation, a proposed contributor to neuropathology. In vitro, scavenger receptors mediate ingestion of fibrillar Abeta (fAbeta) by microglia. Howe...
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